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However, creatine biosynthesis and metabolism are highly dependent on many factors such as diet, hormones, and age [11,12]

See, also, this June 2022 article warning that "life-threatening spikes of digoxinemia could occur, especially after 1-year treatment [for AF] with digoxin." See, also, this August 2022 case report of a dog diagnosed with heart failure and AF and treated with digoxin developed digitalis toxicity and showed a high concentration of plasma digoxin, with these symptoms disappearing 5 days after withdrawal of the digoxin medication

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MCAD, for instance, catalyzes the dehydrogenation of acyl-CoA esters of 4 to 12 carbon atoms (Fig

The convergence of multivariate, univariate, and network-based analyses further supports the robustness of these exploratory findings