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doi: 10.1186/s12967-018-1644-y [DOI] [PMC free article] [PubMed] [Google Scholar] 100

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The activation of TLR4 triggers two signaling pathways: the first one involving TIRAP and MyD88 adaptor proteins begins in the plasma membrane, while the second, depending on TRAM and TRIF, is induced in early endosomes after endocytosis of the receptor governed by a GPI-anchored protein, CD14 [23]