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OTA reduces the expression of several genes regulated by nuclear factor-erythroid 2 p45-related factor (Nrf2) and reduces the expression of antioxidant enzymes through inhibition of Nrf2 [62, 63]

Severe deficiency may lead to more radical treatments

Moreover, we demonstrate that nutrient deprivation of cysteine and methionine decreases cell survival, and synergistically increases lipid peroxidation and cell death when combined with RSL3