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These include: Antacids Metformin Oral contraceptives Methotrexate High-dose niacin Sulfa drugs (e.g., Bactrim) Nitrous oxide (laughing gas) Improving Your Health With an MTHFR Gene Mutation If you suspect your health issues are linked to an MTHFR mutation, here are practical steps to support your body: Optimise your diet Prioritise natural folate (leafy greens, avocado, legumes), choline (eggs, salmon, liver), and B12-rich foods (meat, fish, eggs)

Among antioxidant enzymes, our recent studies have shown evidence of impaired functioning of the enzyme paraoxonase 1 (PON1) associated to high-density lipoprotein (HDL) in individuals with AD, with reduced protein levels and enzyme activity (60, 61)

NSAIDs include ibuprofen, naproxen, indomethacin and ketoprofen