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The median effective dose for dermorphin was calculated to be 5.7 picomoles per mouse, with 95% confidence limits ranging from 4.8 to 6.8 picomoles

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Injectable Dose: 0.1 to 0.2 mg three times weekly Topical Option: Apply serum to target areas twice daily Combined Approach: Injectable 3x weekly plus topical to specific areas Duration: 8 to 12 weeks, can extend longer due to favorable safety profile The timing of GHK-Cu introduction matters for maximum benefit

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