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Dithiolethiones, a class of lipophilic organosulfur compounds, including 5-amino-3-thioxo-3H-(1,2)dithiole-4-carboxylic acid ethyl ester (ACDT) and 3H-1,2-dithiole-3-thione (D3T), have been found to activate Nrf2 signaling pathway and increase cystine/glutamate antiporter system (System Xc) and GSH levels in ferroptosis models [103, 104]

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Depletion of NADPH impairs NO synthesis and lowers glutathione levels, causing an overproduction of oxygen free radicals, which compromises endothelial cell function in blood vessels (Odai et al., 2019

Biochemistry 40 : 1413414142 Klatt P, Molina EP, De Lacoba MG, Padilla CA, Martinez-Galesteo E, Barcena JA and Lamas S (1999) Redox regulation of c-Jun DNA binding by reversible S -glutathiolation

65,66 Cyclosporine has peroxidative properties, induces lipid peroxidation in renal microsomes, and may lead to inactivation of microsomal glucose-6-phosphate activity and toxicity