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When skin expands or shrinks rapidly, collagen and elastin the main proteins that make up the structure of our skin can break apart

While there are physiological differences that would limit inferring conclusions about age-dependent changes in rhythmicity in humans, flies are a useful model because they have a detailed genome annotation and short lifespans, are not difficult to raise, and, like humans, are a diurnal species

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The extracellular microenvironmental pH is 7.4 (basic) in normal tissue which is altered in the cancer microenvironment to 6.8 (acidic), favoring the activity of various metalloproteinases, activating several signal transduction pathways and acting as a chemical barrier for many anticancer drugs that exuberate malignancy and tumor aggression [198,199,200,201,202,203]

Overall, these results suggest the high potential of NP4 as tumor-targeting anticancer agents