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Pegaptanib, a VEGF antagonist with a three-dimensionally structured aptamer, was initially used to inhibit pathological neovascularization and reverse disease progression but was later removed from the market

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it inhibits angiogenesis and induces copper deficiency through chelation (397)

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In vitro studies using both leukemia cell lines and primary human AML blasts has demonstrated direct killing of leukemia cells in a CD1d-dependent manner by iNKT cells, an intriguing finding that warrants further mechanistic investigation (191)

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Jones DP: Redefining oxidative stress

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