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doi: 10.3390/jcm8040561

Under pathological conditions, the following three main mechanisms (oxidative stress, ER stress, and mitochondrial dysfunction) can affect drug metabolism of the liver, and drug metabolites further aggravate liver injury

doi: 10.1038/s41577-022-00792-3 140 MadsenPMDesuHLde Rivero VaccariJPFlorimonYEllmanDGKeaneRWet al

Rau bina Mi ty Nu bn mun tn dng ti a hm lng Glutathione t thc phm sng, cha nu chn, hy m bo ng rut ca bn khe mnh

It has been proposed that reactive oxygen species (ROS) produced by the breakdown of vital mitochondrial enzymes, along with those released during RNA processing, gene transcription, and inflammatory processes, causes liver and kidneys to suffer from oxidative stress and cellular damage (5)