(135) noted in their 2023 review that BCAA overload can activate the mTOR pathway while inhibiting the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) intracellular pathway, leading to IR
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This degradation releases NF-B from the IB complex, facilitating its translocation to the nucleus, where it binds to the promoter region of target genes, including Il-6 , to activate their transcription 29
