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Other antioxidants, including N-acetylcysteine (NAC), resveratrol, and curcumin, have demonstrated anti-inflammatory and neuroprotective effects, further supporting their potential role in FM ( NRF2-activating agents may improve both pain and sleep in FM by enhancing antioxidant defenses, mitochondrial function, and reducing neuroinflammation ( Melatonin supplementation (3 mg/day) has been shown to improve objective and subjective sleep quality, increase 6-sulfatoxymelatonin levels, and enhance total antioxidant capacity in FM patients, suggesting dual chronobiotic and antioxidant benefits ( Mitochondrial-targeted therapies such as CoQ10, alpha-lipoic acid (ALA), and carnitine have been investigated for their role in improving ATP production, reducing oxidative stress, and enhancing cellular metabolism

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Glutathione metabolism in cobalamin deficiency type C (cblC)

This can be noticed as a curve, like a bent carrot, or sometimes an indentation, like an hourglass