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Deficiency causes megaloblastic anemia and subacute combined degeneration of the spinal cord

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Bleomycin-induced mouse fibrosis model and administration of anti-CD38 antibodies All animal studies were conducted in accordance with NIH guidelines for the care and use of laboratory animals and animal protocols were institutionally approved by the Animal Care and Use Committees of Northwestern University and the University of Michigan

Deficiency can lead to fatigue, cognitive impairment, muscle weakness, and other symptoms, making timely diagnosis and treatment critical for overall health

However, the group receiving both AOD9604 and HA showed the most favorable results, suggesting a potential synergistic interaction