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Blood Neoplasia 3(1):100175, 2026

Estrogen modulates brain function by enhancing cerebral blood flow, activating nerve growth factors, and preventing neuronal damage

This reaction catalyzes the generation of ROS, further promoting lipid peroxidation and leading to lipid peroxide accumulation, ultimately inducing ferroptosis (57) (Fig

Without specific biomarkers, it is difficult to evaluate the therapeutic effects of ferroptosis-targeting agents in clinical trials and adjust treatment plans accordingly