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Additional roles of ALDH2: In addition to breaking down alcohols, ALDHD also metabolizes:[ref] Retinol (vitamin A) Bile acids lipid peroxidation products neurotransmitter metabolites Studies link genetic variants in ALDH2 to increased risk of Alzheimers disease, possibly due to the decreased ability to break down lipid peroxidation products in the brain

Alfhili MA, Alyousef AM, Alsughayyir J

Thus, these several data highlight the knockdown of the normal antioxidant response in FRDA particularly with respect prolonged redox stress, and coincide with the earlier reports of cytoskeletal abnormalities reported in FXN-deficient cells (reviewed below)

GSH depletion causes ferroptosis in RPE cells To evaluate the mechanism of cell death in GSH-depleted cells, we treated RPE cells with various cell death pathway inhibitors including ferroptosis inhibitors ferrostatin-1 (Fer-1, 8 M), liproxstatin-1 (Lip-1, 600 nM), iron chelator deferoxamine (DFO, 80 M), pan-caspase inhibitor z-VAD-fmk (30 M) to inhibit apoptosis, autophagy inhibitor 3-methyladenine (3-MA, 10 mM), and lysosomal inhibitor bafilomycin A1 (Baf-A1, 75 nM)

Several researchers additionally propose the hypothesis of a feedback loop linking oxidative stress with iron accumulation [66, 67]