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Mitochondria-targeted nanozymes eliminate oxidative damage in retinal neovascularization disease

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Collectively, these coordinated effects suggest that exerkines may provide a more robust and physiologically integrated defense against oxidative stressdriven retinal damage

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First, the formation of y-glutamyl cysteine from glutamate and cysteine, mediated by the enzyme Y-glutamylcysteinesynthetase, followed by the formation of GSH by the activity of GSH synthetase, which uses y-glutamyl cysteine and glycine as substrates (Meri et al., 2007)