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& Klionsky, D

Enteric glial cells counteract Clostridium difficile toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways

Nrf2 overexpression inhibited the Tat effects, reducing the intracellular ROS and increasing intracellular levels of GSH [28]

Conclusion We found evidence for the role of lower GSH in patients with MDD in the occipital region of the brain, a difference which is not found in other brain regions or in combined brain region studies