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Researchers have linked higher IGF-1 levels to greater bone mineral density in older female subjects

If you're not getting enough B12, you can experience anemia, fatigue, weakness, constipation, decreased appetite, weight loss, dizziness, lightheadedness, confusion, poor memory, soreness of your tongue and mouth, and tingling and numbness in your hands and feet, according to Harvard Health Publishing

In some cases, the ligament rupture may also tear off a piece of the bone (avulsion fracture)

Mitochondrial function and toxicity: Role of the B vitamin family on mitochondrial energy metabolism

Consistency: Have you been dosing daily without significant gaps