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Glutathione and glutaredoxinkey players in cellular redox homeostasis and signaling

The antioxidant activity of GSH intermediated via thiol (-SH) of its cysteine residue upon its interaction with ROS or electrophiles and the GSH oxidized to GSSG (oxidized Glutathione), the GSSG will reduce to GSH by Glutathione reductase (GR), the activity of GR is therefore very important to keep the antioxidant power of mammalian cells, while GSH/GSSG ratio is an indicator for redox balance in the cell

Other metabolic reactions only detected in HepaRG incubations were hydroxylamine formation (MT1.4) of 4MeS-NE-BP and N,N -bis-dealkylation (MT2.5) of 4MeS-P-BP

Proc Natl Acad Sci U S A (2009) 106(29):119138.10.1073/pnas.0812138106 39 BakerM

Sequence types (STs) for each genome were derived with Kleborate, which performs sequence alignment against an established MLST scheme 2 comprising seven loci (more information can be found in the associated BIGSdb resource: Pan-genome analysis We constructed a pan-genome of the 656 K