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Drilon, A

Moreover, PGC-1 also interacts with PPAR, the master regulator of FAO to upregulate the expression of FAO-related genes, such as CPT1, SLC25A20 and CPT2 (Tachibana et al., 2009

Such Sirts have the potential to downregulate the NF-B pathway, which helps reduce neuroinflammation (Paxinou et al., 2001) Sirt2 has been reported to deacetylate NOD-like receptor pyrin domain containing 3 (NLRP3) and prevent aging-related chronic inflammation (Li et al., 2021), while Sirt3 inhibits NLRP3 by reducing mitochondrial damage and mtDNA release (He et al., 2020)

Neuron 90 , 521534 (2016)

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