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3 Peripheral neuropathy is a common complication of both T1DM and T2DM, and in 4050% of these individuals, a detectable condition develops within a decade of diagnosis of the primary condition

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Glutathione participates in: neutralising reactive oxygen species supporting detoxification pathways in the liver maintaining intracellular balance It also interacts with enzymes such as glutathione peroxidase, which plays a role in protecting cells from oxidative damage

Second, lipid peroxidation control serves as a critical regulatory node, with pathogens modulating GPX4, GSH, and antioxidant pathways to either promote or prevent ferroptosis depending on their replication strategies

Environmental parameters such as temperature, pH, and incubation period also play a crucial role