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CircRNAs CircRNAs, widely present in eukaryotic cells and formed through back-splicinga specialized alternative splicing mechanism of precursor mRNAs, exhibit evolutionary conservation and exceptional stability, which harbor miRNA response elements (MREs) that sequester endogenous miRNAs, thereby modulating gene expression by acting as miRNA sponges and participating in diverse biological processes, including cardiovascular diseases, proliferation, and inflammation [121]

CAT is a tetrameric enzyme with a molecular mass of roughly 240 kDa and four identical, tetrahedrally organized subunits, each measuring 60 kDa and containing one ferriprotoporphyrin group [91]

It is formed through the reaction of ROS with polyunsaturated fatty acids in cellular membranes

[ Chen N, Harris TW, Antoshechkin I, Bastiani C, Bieri T, Blasiar D, Bradnam K, Canaran P, Chan J, Chen CK, et al: WormBase: a comprehensive data resource for Caenorhabditis biology and genomics

Alcohol makes this problem worse in two ways: it directly worsens the toxic effects of GHB, and it impairs the judgment needed to dose carefully or recognize early warning signs