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In the cumulative toxicity test, Kunming mice were injected with 500 mg kg 1 LAAM GSH-CQDs on days 0, 4, and 7, respectively, and the dose was increased to 1000 mg kg 1 on days 10 and 13, with an accumulated dose of 3500 mg kg 1

Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]

It is indicated for the treatment of OAB symptoms, including urinary urgency, increased urinary frequency, and urge urinary incontinence (UUI)

Blood 102 (13), 45764581