glutathione in epigenetics An interactive network of the redox and methylation factors Glutathione synthesis from glycine and

Biliverdin may affect NF-B through at least two pathways

In the past, the two-hit hypothesis was used to explain the mechanism of NAFLD and NASH pathophysiology, but currently, the multiple-hit model is suggested ( NASH and NAFLD begin with the excessive accumulation of triglycerides (TG) in the liver ( de novo lipogenesis from glucose and fructose, and (III) dysregulated adipocytes' triglyceride lipolysis leading to excessive fatty acid transport to the liver (65), adipokine dysregulation (66), hepatic ATP depletion (67), uric acid-induced hepatocyte mitochondrial dysfunction (68), and the effects of intestinal microbiota products (69)

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Zhou Y, Jin L, Kong F, Zhang H, Fang X, Chen Z,

Free Radic Biol Med 44(5):723738