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Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H

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Vitamin D3 metabolites enhance the NLRP3-dependentsecretion of IL-1

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(2020) discovered that oroxylin A could boost peroxisome proliferator-activated receptor gamma coactivator 1 alpha/mitofusin 2 (PGC-1/Mfn2) signaling, reduce ROS accumulation, prevent NLRP3 inflammasome activation, and block the classical caspase-1-dependent pyroptotic pathway, thereby reducing alcohol-induced liver cell damage

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