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Dynamic bioenergetic alterations in colorectal adenomatous polyps and adenocarcinomas

However, if the antioxidant defense systems such as GPX4 or ferroptosis suppressor protein 1 (FSP1) fail to neutralize this oxidative stress, the signal intensifies beyond repairable levels (Liu et al., 2022b)

10.1002/path.2277 153 XueX

Nat Rev Cancer (2011) 11(5):32537.10.1038/nrc3038 57 AnastasiouDPoulogiannisGAsaraJMBoxerMBJiangJKShenMet alInhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses