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Abstract Curcumin, a natural polyphenol derived from Curcuma longa , exhibits potent multimodal anticancer activity by modulating critical oncogenic pathways (e.g., NF-B, STAT3, PI3K/Akt/mTOR), inducing apoptosis, suppressing angiogenesis, and reversing multidrug resistance (MDR)

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Not through any techno-fantasies of biohacking or wonder-drug supplements but largely with highly rigorous, detailed and personalized monitoring and treatment of our nutrition, sleep, exercise and mental health

166169 (2) Follow-up cohorts of MAFLD patients with comprehensive clinical phenotypes and biological specimens should be established, utilizing multi-omics technologies for non-invasive assessment of MASH and fibrosis

Compared with those in adjacent normal tissues, significantly elevated levels of GPx1 in tumor tissues have been observed in glioblastoma multiforme, renal papillary cell carcinoma (KIRP), acute myeloid leukemia (AML), low-grade glioma (LGG), ovarian serous cystadenocarcinoma, pancreatic adenocarcinoma, skin melanoma, testicular germ cell tumor, thyroid cancer, and endometrial cancer (Wei et al