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Released into the extracellular space, HMGB1 in turn stimulates production of massive inflammatory cytokines, which further expand the inflammatory response (33, 34)

An increased carcinogenic risk with the development of secondary malignancies in animals/patients treated with cisplatin has also been reported (Kempf and Ivankovic, 1986

coli : Escherichia coli FDR: False discovery rate, the fraction of positive reports that are incorrect GAL1 promoter: Galactose-inducible promoter sequence (originating from the GAL1 gene) GBT: Gradient-boosted trees, a machine learning algorithm gnomAD: Genome Aggregation Database LC-MS/MS: Liquid chromatography followed by tandem mass spectrometry MAF: Minor allele frequency, the frequency of a given minor allele MAT cys4::KanMX his31 leu20 lys20 ura30 : Yeast strain of mating type alpha, carrying a kanamycin resistance cassette that replaces the CYS4 locus, as well as carrying null alleles for LEU2 , LYS2 and URA3 , which convey auxotrophies to leucine, lysine, and uracil mRNA: Messenger ribonucleic acid NGS: Next-generation sequencing technology NMD: Nonsense-mediated decay NNK: Degenerate codon consisting of two random nucleotides (A/C/G/T) followed by a single keto-nucleotide (G/T) N-terminus: Amino-group terminus of a protein sequence OMIM: Online Mendelian Inheritance in Man, a database of Mendelian disorders ORF: Open reading frame, a nucleotide sequence that stretches form a start to a stop codon

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