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The coordination among these snRNPs, along with numerous other splicing factors such as serine/arginine-rich (SR) proteins and heterogeneous nuclear ribonucleoproteins (hnRNPs), regulates the assembly of the spliceosome, splicing accuracy and the selection of alternative splice sites 33

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Methods: Here we describe how a Quantitative Systems Pharmacology (QSP) model, NAFLDsym, was leveraged in discovery and development decision-making to select the targets, identify mechanism-based biomarkers, and simulate clinical trials to predict the effects of targets/combination of targets in NASH virtual patients

Copper peptides are small molecules made of a short chain of amino acids bound to a copper ion