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Propidium iodide was excited with an argon laser tuned at 488 nm

Processing of cholesterol and protein gives propionyl-CoA that is converted to methylmalonyl-CoA, which is used by MUT enzyme to make succinyl-CoA

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In contrast, the -arrestin-mediated pathway involves the recruitment of -arrestin to activated 2-AR, promoting receptor internalization and activation of downstream signaling cascades, including extracellular signal-regulated kinase (ERK) activation and nuclear translocation 39,40