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Similarly, studies have shown that mast cell-derived tryptase can degrade cartilage ECM components and activate MMP13, thereby inducing joint inflammation, chondrocyte apoptosis, and cartilage destruction (133)

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Identification of metabolites in CL1-0 and CL1-5 with different radio-sensitivities Since CL1-0 and CL1-5 cells presented inherently different metabolite profiles, the loading plots from the PCA plot were used to obtain the ppm value for further identification of specific metabolites from these two cell lines ( Figure 4 )