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356 In the brain sample of AD patients, mitophagy levels decreased 3050% compared with the normal ones, at the meantime downregulated PINK1 and BNIP3L were observed

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In addition, patients with tophi are often at risk for uric acid-related kidney stones, since they may be over-producers of uric acid and have elevated 24-hour urinary uric acid

These leukocytes are the phagocytic cells of the immune system and they utilize NADPH to generate superoxide radicals from molecular oxygen in a reaction catalyzed by NADPH oxidase