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This suggests that Treg consumption is a key additional mechanism of action of these mAbs ( Figure 2 It was found that patients with at least a partial response to Daratumumab showed higher CD38 expression on MM cells ( in vitro

Of relevance, recent evidence indicates that SAM exerts anti-inflammatory effects by reducing the expression of the proinflammatory cytokine tumor necrosis factor-alpha (TNF) and increasing the expression of the anti-inflammatory cytokine interleukin 10 (IL-10)

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