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HDL has antioxidant properties that safeguard LDL from oxidative damage and help eliminate oxidized lipids, thereby inhibiting the generation of intracellular ROS

65 Despite efforts have been made to repair mtDNA with various mechanisms, the mutation rate of mtDNA remains higher than nuclear DNA

However, cytosolic H 2 O 2 generated by APx1 deficiency can trigger the adaptation to oxidative stress [27]

46 Emotional Stress and Glaucoma As described earlier, closed-angle glaucoma can be related to a structural abnormality in the eye where a narrow angle between the iris and cornea impedes the outflow of aqueous fluid

Lipid peroxidation produces damaging byproducts such as malondialdehyde (MDA) and 4-hydroxynonenal (HNE), which impair membrane integrity and worsen neurological and cardiovascular disorders