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Izadi A, Shirazi S, Taghizadeh S, Gargari BP

In contrast, metformin is commonly used during pregnancy for diabetes and polycystic ovary syndrome, and is compatible with breastfeeding

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Any log-jam caused either by high SAH or by homocysteine can slow down SAMe synthesis (via negative feedback)

More notably, they highlight that competition between lactylation and acetylation may arise directly from shared catalytic machinery: When multiple acyl-CoA species coexist in the nucleus, they may compete for occupancy of the same acyl-CoA channel within p300, thereby influencing the balance between distinct PTMs