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Amantadine: A phase 3 trial was conducted to test the efficacy of the drug on alleviating dyskinesia and OFF time for PD patients and LD-induced dyskinesia

For example, when Pharm-IF, a pharmacophore-based interaction fingerprint, was used as input to several ML algorithms for ranking small molecule docking poses, the SVM-based model outperformed other algorithms and docking scores in terms of enrichment rates [183]

Memantine add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: Yandomized, double-blind, placebo-controlled study

Iranmehr discovered that the upregulation of myotubularin-related protein 4 (MTMR4), tropomodulin 3 (TMOD3), and vascular cell adhesion molecule 1 (VCAM1) genes could potentially impair the bone morphogenetic protein (BMP) pathway, hinder cell migration and tissue repair, impact leukocyte adhesion to endothelial cells, and modulate endothelial cell inflammatory reactions