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Additionally, inflammation limits the usefulness of plasma/serum testing

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Further investigations revealed that ACSL4 mediates ferroptosis and neuroinflammation in EAE mice, enhancing T cell receptor (TCR) signaling and activating T cells, thereby participating in immune regulation and accelerating EAE progression

doi: 10.1007/s11738-013-1389-4 55 Otulak-KozieK.KozieE.BujarskiJ

The PTC cell lines selected for the in vitro experiments represent some of the most common mutational signatures observed in thyroid cancer, particularly BRAF V600 E is found in more than 60% of PTCs and purports more aggressive tumor phenotype