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10.1016/S0140-6736(15)01120-4 43

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Second-line treatments, known as device-aided therapies (DATs), have been developed for LDRCs, such as continuous subcutaneous apomorphine infusion (CSAI), continuous subcutaneous foslevodopafoscarbidopa, infusion of levodopacarbidopa intestinal gel (LCIG entacapone) and subthalamic deep brain stimulation