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doi: 10.3390/cells13221880

Artemisinin originates from isopentenyl diphosphate (IPP) or dimethylallyl diphosphate (DMAPP) via the methylerythritol phosphate (MEP) pathway in the plastid or via the mevalonate (MVA) pathway in the cytosol 70

The animal studies used both local application at the injury site and systemic administration (intraperitoneal and intragastric), with both routes showing significant effects

Use a drilling machine to remove 90% of the material

After an interim analysis, mAb114 monotherapy and REGN-EB3 were both found to be superior to ZMapp with respect to the primary outcome and patient mortality 179 , and were approved by the FDA for the treatment of EVD in 2020 (refs 180,181 )