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A protein aggregation inhibitor, leuco-methylthioninium bis(hydromethanesulfonate), decreases alpha-synuclein inclusions in a transgenic mouse model of synucleinopathy

doi: 10.1016/j.tips.2020.07.003 49 CuadradoA.RojoA

Nivolumab in previously untreated melanoma without BRAF mutation

Biotin has been shown to ameliorate neuroinflammatory dysfunctions, and in animal models, a novel biotin complex called bionicotinate magnesium (MgB) improved social behavior, learning, and memory deficits (58)

In a controlled hemorrhage mouse model, HbPs maintained MAP, improved venous oxygen partial pressure, and restored tissue oxygen supply, demonstrating a promising application potential