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doi: 10.1038/s41569-021-00569-6 96 MuQWangQYangYWeiGWangHLiaoJet al

Such metabolic rewiring towards increased aerobic glycolysis also formed the basis for -glucan-induced trained immunity of monocytes and was associated with epigenetic histone modifications and increased expression of genes involved in glycolysis triggered by the AKT-mTOR-HIF1 pathway (Cheng et al., 2014