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The hypoxic environment of the RA joint cavity and abnormal mitochondrial respiration of FLSs lead to an increase in glycolytic activity and Warburg effect (70)

While renal dysfunction progresses, the most important indicators of oxidative stress are plasma F2-isoprostanes, 8-oxo-7,8-dihydro-2-deoxyguanosine, malondialdehyde (MDA), carbamylated proteins, advanced oxidation protein products, asymmetric dimethylarginine, and oxidized lipoprotein particles (138, 141, 142)

Nutrients 15 , 3444 (2023)

Interestingly, GLT1 which is located in astrocytes showed diminished functional activity that eventually decreased Glu clearance and increased epileptogenic foci (Peterson and Binder, 2019