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In contrast, Asian populations including those in Japan, Taiwan (China) and Hong Kong (China) demonstrate substantially lower prevalence (0.10.7/100,000), suggesting potential genetic and/or environmental modifying factors (Wise, 2010

Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis

This was accompanied by depletion of GSH content

Subjects were initially treated for 6 months of on-demand therapy and then randomized to 12 months of either a standard prophylaxis regimen (20 to 40 IU/kg every 48 hours) or PK-driven prophylaxis regimen (20 to 80 IU/kg every 72 hours)

Diabetes Care 39 , 15631570 (2016)