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However, more research should focus on the long-term effects of NR or other NAD + precursors in neurodegenerative patients

Disclosures: Arunkumar Krishnan: Nothing to Disclose, Diptasree Mukherjee: Nothing to Disclose, Carolin Schneider: Nothing to Disclose, Tinsay Woreta: Nothing to Disclose, Saleh Alqahtani: Nothing to Disclose 1161 NOTCH SIGNALING DISRUPTION AND CELLULAR CROSSTALK: DISSECTING THE PATHOPHYSIOLOGY OF BILE DUCT PAUCITY IN ALAGILLE SYNDROME USING HUMAN LIVER ORGANOIDS Marie-Agns M'CALLUM 1 Quang Toan PHAM 1 Kristen Vieira-Lomasney 1 Eytan Haddad 1 Silvia Selleri 1 Massimiliano Paganelli 1 , 1 Liver Tissue Engineering and Cell Therapy Laboratory, CHU Sainte-Justine, Universit de Montral Background: Alagille syndrome (ALGS) is a multisystemic genetic disorder resulting in severe liver disease characterized by intrahepatic bile duct paucity

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Glossop JR, Emes RD, Nixon NB, Haworth KE, Packham JC, Dawes PT, et al

Applications : Suitable for in vitro research, cellular studies, and other laboratory-based investigations