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These results establish the importance of B cells and adaptive immunity in insulin resistance and suggest new diagnostic and therapeutic modalities for managing the disease. Anti-NMDA receptor encephalitis and late onset autism are recently recognised and related autoimmune disorders involving antibodies to NMDA (glutamatergic) receptors with prodromal symptoms reminiscent of a viral infection and that result in a wide range of movement and neuropsychiatric symptoms and neuroinflammation

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Chaperones and Protein Quality Control Chaperone proteins play an important role in the post-translational maturation of nascent proteins by facilitating their folding

For inhibition of thioredoxin reductase or glutathione reductase activity, cells were subsequently treated with 1 M auranofin (Sigma Aldrich, Darmstadt, Germany) or 50 M 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) (Sigma Aldrich, Darmstadt, Germany) respectively for 1 h