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Description

A "98%" claim with no attached HPLC trace is just a number

The tirzepatide studies used the maximum approved dose of 2.4 mg

Blind cage coding and automated video analysis (EthoVision, TopScan) are recommended Too low n : prior power analysis, n 8 minimum for rodent behavioural tests No positive control : without memantine, donepezil or scopolamine depending on the paradigm, impossible to judge if the model is functional No dose-response : a single tested dose is insufficient to conclude

Cellular senescence modulation : May delay entry of cells into senescent states through reduced oxidative and glycation damage

Comparison to Other Senolytic Therapies To contextualise FOXO4-DRI, lets compare it to other senolytic approaches or peptides you may be aware of (helpful given your clinics peptide focus)