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Furthermore, overactivation of glutamate receptors, such as NMDA receptors, raises intracellular Ca2+ levels

2b and c)

102 In vitro treatment with 1-h H 2 O 2 demonstrated that the catalytic activity of POLG was reduced to 50% of the original level with significantly lower DNA binding efficiency

Nevertheless, progressive neurodegeneration can be induced by microglia-specific overexpression of pSYN in the absence of pSYN in dopaminergic cells (194)