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Taken together, our results suggest a conserved influence of intermediate filament association with aggresomes and neuronal extrusions that eject potentially toxic material

In SURMOUNT 1, tirzepatide induced a mean BW reduction of 15.0%, 19.5% and 20.9% with 5 mg, 10 mg and 15 mg, respectively compared to 3.1% obtained with placebo at 72 weeks 34

Following cell treatment with proteasome inhibitors, stably expressed ATG12 binds to and inactivates the antiapoptotic proteins Bcl-2 and Mcl-1 via a BH3-like motif, resulting in BAX activation, mitochondrial release of cytochrome c, and enhanced chemosensitivity [84]

Hoppel, Quantification of carnitine and acylcarnitines in biological matrices by HPLC electrospray ionization-mass spectrometry, Clinical Chemistry 54 (9) (2008) 1451-1462