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Conversely, cancer stem cells (CSCs) preferentially rely on OXPHOS to meet the bioenergetic demands required for maintaining stemness, thereby contributing to therapeutic resistance and tumor recurrence [68]

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Early warning signs of Vitamin B12 deficiency often include persistent fatigue and weakness, brain fog, memory and concentration issues, a smooth or sore tongue (glossitis), pale or yellowish skin, and tingling sensations in hands or feet

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In three such high fat diet studies, metformin treatment reduces cognitive deficits ( Table 1 Studies investigating the effect of metformin on neurodegeneration in rodent models