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Medians We analyzed Pfcrt 76/Pfmdr1 86 haplotypes in the following combinations: K76-N86, K76-86Y, 76T-N86, 76T-86Y

5-Amino-1MQ was selected for further work because of its potency, permeability and selectivity in the tested systems

Importantly, animals were singly housed to eliminate the exchange and cross-contamination of intestinal microbiomes, a factor that potentially biases studies with group-housed animals by minimizing microbiome variations for co-housed animals within a cohort