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Electronic databases such as Medline/PubMed, ScienceDirect, Scopus, TRIP database, and Web of Science were verified to find both pre-clinical pharmacological/immunological studies and clinical trials regarding Taxol derivatives, using for searching the following MeSH terms: Antineoplastic Agents/chemistry, Antineoplastic Agents/pharmacokinetics, Antineoplastic Agents/pharmacology, Apoptosis/drug effects, Clinical Trials as Topic, Drug Resistance, Neoplasm/physiology, Humans, Microtubules/drug effects, Mitosis/drug effects, Neoplasms/drug therapy, Taxoids/chemistry, Taxoids/pharmacokinetics, Taxoids/pharmacology, Paclitaxel, Paclitaxel/administration and dosage, Prostatic Neoplasms, Castration-Resistant/drug therapy, Docetaxel, and Taxoids/therapeutic use. This study analyzed articles that explored the pharmacological, immunological reprogramming, and subcellular analysis of drugs in pre-clinical models using cell lines or animal models

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In response to the request that CMS offer support for adjusting to the new cost scoring methodology, we note that clinicians would not need to do anything different under this new cost scoring methodology since CMS automatically scores cost measures using claims data